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Background
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Synonyms:
BML-278, N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
Sirt activator based on a dihydropyridine structural scaffold. EC150 (effective concentration able to increase enzyme activity by 150 %) is 1 μM for Sirt1, 25 μM for Sirt2, and 50 μM for Sirt3. The compound is active in whole cells and arrests cell cycle at G1/S phase in U937 cells.
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