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  • 產品名稱：Boc-D-FMK

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  • 產品廠商：Biovision
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簡單介紹：
Boc-D-FMK
詳情介紹：
Purpose A caspase family inhibitor
Sequence Boc-Asp(OMe)-FMK
Characteristics A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity > 95?% by HPLC
Chemical Name Boc-D-FMK, Boc-D-fluoromethylketone, Caspase Inhibitor (fluoromethylketone)
Formula C??H??FNO?
Permeability Cell-permeable
Solubility DMSO (20 mM)
Molecular Weight 263.26 g/mol
Application Notes We recommend using 2-10 μM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Solid, Lyophilized
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 12 months
Product cited in: Natoni, Murillo, Kliszczak, Catherwood, Montagnoli, Samali, ODwyer, Santocanale: "Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells." in: Molecular cancer therapeutics, Vol. 10, Issue 9, pp. 1624-34, 2011 (PubMed).

Oshikawa, Nagao, Wu, Kurosu, Miura: "c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway." in: The Journal of biological chemistry, Vol. 286, Issue 35, pp. 30263-73, 2011 (PubMed).

Kurosu, Ohki, Wu, Kagechika, Miura: "Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway." in: Cancer research, Vol. 69, Issue 9, pp. 3927-36, 2009 (PubMed).

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