Comment
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Inhibits Stat3.Stat3 complex formation and Stat3-DNA binding activity in vitro (IC = 86 ± 33 μM) and Stat3-dependent transcriptional activities. S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo
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