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產(chǎn)品詳情

  • 產(chǎn)品名稱：JumonjiHDMInhibitor,JIB-04

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
JumonjiHDMInhibitor,JIB-04
詳情介紹：
Purpose A potent jumonji HDM inhibitor
Characteristics JIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC?? values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). JIB-04 is not a competitive inhibitor of α-ketoglutarate , it selectively inhibits viability of several human cancer cell lines with little toxicity towards normal cells, and also diminishes tumor growth in xenograft mouse models.
Purity ≥ 98?% by HPLC
Chemical Name 5-Chloro-2-[(E)-2-[phenyl(pyridin-2?-yl)methylidene]hydrazin-1-yl]pyridine; NSC693627
Formula C??H??ClN?
Permeability Cell-permeable
Solubility DMSO (approx. 20 mg/mL)
Molecular Weight 308.76 g/mol
CAS-No 199596-05-9
Comment

JIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). JIB-04 is not a competitive inhibitor of -ketoglutarate , it selectively inhibits viability of several human cancer cell lines with little toxicity towards normal cells, and also diminishes tumor growth in xenograft mouse models
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
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