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產(chǎn)品詳情

  • 產(chǎn)品名稱：SYKInhibitor,R406

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
SYKInhibitor,R406
詳情介紹：
Purpose A potent SYK (Spleen Tyrosine Kinase) inhibitor?
Characteristics

R406 is a potent SYK (Spleen Tyrosine Kinase) inhibitor (IC?? = 41 nM). R406 strongly inhibits SYK but not Lyn, and displays 5-fold less potency towards FLT3. R406 induces apoptosis in diffuse large B-cell lymphoma cell lines. It blocks B cell receptor signaling through inhibition of SYK autophosphorylation of Y525/Y526 and SYK-dependent phosphorylation of the B-cell linker protein.

Smiles: CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C

InChi: InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)

Inchi Key: NHHQJBCNYHBUSI-UHFFFAOYSA-N
Purity ≥ 98?% by HPLC
Chemical Name 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Formula C??H??FN?O?
Permeability Cell-permeable
Solubility DMSO (>5 mg/mL)
Molecular Weight 470.45 g/mol
CAS-No 841290-80-0
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months
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