產(chǎn)品詳情
簡單介紹:
rATXIINeurotoxin2,ToxinATX-II,As2,Anemoniaviridistoxin2,Av2)
詳情介紹:
Sequence | GVPCLCDSDG PSVRGNTLSG IIWLAGCPSG WHNCKKHGPT IGWCCKQ. |
Specificity | ATX II is a potently modulates voltage-gated Na+ channel gating kinetics by delaying its inactivation and prolonging the action potential of excitable membranes. ATX II has been used as a powerful activator of TTX-sensitive and insensitive Na+ channels in various excitable tissue and cell types1-4. |
Characteristics |
Source: Anemonia sulcata, Anemonia viridis (Mediterranean snakelocks sea anemone). Molecular formula: C213H324N64O60S6. Disulfide bonds between Cys4-Cys44, Cys6-Cys34, and Cys27-Cys45. |
Purity | > 98 % |
Molecular Weight | 4935 |
Application Notes | 10-100 nM |
Restrictions | For Research Use only |
Format | Lyophilized |
Reconstitution |
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). Concentration after reconstitution: Dissolving 50g in 1.013ml will provide a stock solution of 10 M. |
Handling Advice | Soluble in Water. |
Product cited in: |
Brand, Seeger, Alzheimer: "Enhancement of persistent Na+ current by sea anemone toxin (ATX II) exerts dual action on hippocampal excitability." in: The European journal of neuroscience, Vol. 12, Issue 7, pp. 2387-96, 2000 (PubMed).
Tripathy, Resch, Xu, Valdivia, Meissner: "Imperatoxin A induces subconductance states in Ca2+ release channels (ryanodine receptors) of cardiac and skeletal muscle." in: The Journal of general physiology, Vol. 111, Issue 5, pp. 679-90, 1998 (PubMed). Nishio, Ohmura, Kigoshi, Muramatsu: "Supersensitivity to tetrodotoxin and lignocaine of sea anemone toxin II-treated sodium channel in guinea-pig ventricular muscle." in: British journal of pharmacology, Vol. 104, Issue 2, pp. 504-8, 1992 (PubMed). Tesseraux, Gülden, Wassermann: "Cultured myotubes from skeletal muscle of ***** rats. Characterization and action of Anemonia sulcata toxin II." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 336, Issue 2, pp. 232-9, 1988 (PubMed). Romey, Abita, Schweitz, Wunderer, Lazdunski: "Sea anemone toxin:a tool to study molecular mechanisms of nerve conduction and excitation-secretion coupling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 73, Issue 11, pp. 4055-9, 1977 (PubMed). |