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  • 產品名稱:Caspase-1InhibitorZ-YVAD-FMK

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  • 產品廠商:Biovision
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簡單介紹:
Caspase-1InhibitorZ-YVAD-FMK
詳情介紹:
Purpose A caspase-4 inhibitor
Sequence Z-Tyr-Val-Ala-Asp(OMe)-FMK
Characteristics PubChem CID: 16760349
A synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity > 99?% by HPLC
Chemical Name Z-YVAD-FMK, Caspase-1 Inhibitor, Z-YVAD fluoromethylketone
Formula C??H??FN?O?
Permeability Cell-permeable
Solubility DMSO
Molecular Weight 630.7 g/mol
Application Notes We recommend using 1000X dilutions for inhibiting caspase-3 activity in Jurkat cell culture (e.g., Add 1 μL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Liquid
Concentration 10 mM
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 6-12 months
Supplier Images
 image for Caspase-1 Inhibitor Z-YVAD-FMK (ABIN412351) Caspase-1 Inhibitor Z-YVAD-FMK
Product cited in: Lhomme, Esser, Riva, Scheen, Paquot, Piette, Legrand-Poels: "Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages." in: Journal of lipid research, Vol. 54, Issue 11, pp. 2998-3008, 2013 (PubMed).

Shao: "Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models." in: Human reproduction (Oxford, England), Vol. 25, Issue 3, pp. 584-7, 2010 (PubMed).

Hewinson, Moore, Glover, Watts, MacKenzie: "A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8410-20, 2008 (PubMed).

Arai, Miyake, Voit, Nemoto, Wakeland, Grummt, Miyazaki: "Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 7, pp. 2289-94, 2007 (PubMed).

Cruz, Rinna, Forman, Ventura, Persechini, Ojcius: "ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 2871-9, 2007 (PubMed).

Klumpp, Rycyk, Chen, Thumbikat, Sengupta, Schaeffer: "Uropathogenic Escherichia coli induces extrinsic and intrinsic cascades to initiate urothelial apoptosis." in: Infection and immunity, Vol. 74, Issue 9, pp. 5106-13, 2006 (PubMed).

Lin, Cheung, Wu, Chen, Lin, Chen, Liou, Shyue, Wu: "15d-prostaglandin J2 protects brain from ischemia-reperfusion injury." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 26, Issue 3, pp. 481-7, 2006 (PubMed).

Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Yen, Mar, Craciunescu, Edwards, Zeisel: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).

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