Characteristics
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Cell-permeable. A Sirtuin 2 (SIRT2) inhibitor (IC50 = 35 μM). Promotes inclusion formation in cellular models of both Huntington,'s disease and Parkinson,'s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces alpha-synuclein-mediated toxicity. Synonyms: 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline, CPNQ
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