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產(chǎn)品詳情

  • 產(chǎn)品名稱：JAKInhibitor,Pyridone6

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
JAKInhibitor,Pyridone6
詳情介紹：
Purpose A potent JAK inhibitor
Characteristics ?JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC?? values of 15, 1, and 5 nM, respectively. Displays signi?cantly weaker affinities (IC??s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC?? values of 50-100 nM.
Purity ≥ 97?% by HPLC
Chemical Name 2-?(1,?1-?Dimethylethyl)-?9-?fluoro-?1,?6-?dihydro-?7H-?benz[h]imidazo[4,?5-?f]isoquinolin-?7-?one; Pyridone 6; CMP 6
Formula C??H??FN?O
Permeability Cell-permeable
Solubility DMSO (5 mg/mL)
Molecular Weight 309.3 g/mol
CAS-No 457081-03-7
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for JAK Inhibitor, Pyridone 6 (ABIN1888988) JAK Inhibitor, Pyridone 6
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