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Purpose
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A potent Brutons Tyrosine Kinase (BTK) inhibitor
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Characteristics
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A potent and highly selective small-molecule inhibitor of Bruton's tyrosine kinase (BTK) (IC50= 0.5 nM) with potential antineoplastic activity. It.binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK.
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Purity
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≥ 98?% by HPLC
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Chemical Name
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2-propen-1-one, 1-((3R)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo(3,4-d)pyrimidin-1-yl)-1-piperidinyl)-; Ibrutinib; CRA-032765
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Formula
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C??H??N?O?
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Permeability
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Cell-permeable
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Solubility
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DMSO (> 80 mg/mL)
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