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產(chǎn)品詳情
  • 產(chǎn)品名稱:Galunisertib(LY2157299)

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  • 產(chǎn)品廠商:TargetMol
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Galunisertib(LY2157299)
詳情介紹:
Purpose Galunisertib is an orally available, small molecule antagonist of the tyrosine kinase transforming growth factor-beta (TGF-b) receptor type 1 (TGFBR1), with potential antineoplastic activity. Upon administration, galunisertib specifically targets and binds to the kinase domain of TGFBR1, thereby preventing the activation of TGF-b-mediated signaling pathways. This may inhibit the proliferation of TGF-b-overexpressing tumor cells. Dysregulation of the TGF-b signaling pathway is seen in a number of cancers and is associated with increased cancer cell proliferation, migration, invasion and tumor progression.
Characteristics Target: TGF-beta/Smad inhibitor
Receptor: TβRI
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 99.90?%
Formula C22H19N5O
Solubility Soluble in DMSO
Molecular Weight 369.42 g/mol
CAS-No 700874-72-2
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months
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