久热精品人妻视频,人人妻人人妻人人av,亚洲无码天堂在线观看,澳门成AV人片在线观看无码,久久国产精品二区,亚洲无码免费观看视频

產品詳情
所在位置: 首頁> 產品目錄> 輔助試劑>
  • 產品名稱:rCharybdotoxin

  • 產品型號:
  • 產品廠商:BioLeaf
  • 產品文檔:
你添加了1件商品 查看購物車
簡單介紹:
rCharybdotoxin
詳情介紹:
Sequence QFTNVSCTTS KECWSVCQRL HNTSRGKCMN KKCRCYS.
Specificity Charybdotoxin is a potent selective inhibitor of high conductance (maxi-K), different medium and small conductance Ca2+-activated K+ channels, as well as a voltage-dependent K+ channel (Kv1.3).
Characteristics Source: Leiurus quinquestriatus hebraeus (Yellow scorpion).
Molecular formula: C176H280N58O55S7.
Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35.
Purity > 98 %
Background Inhibition of mSlo channels heterologously expressed in HEK293 cells by Charybdotoxin. mSlo channel currents, before and during application of 100nM rCharybdotoxin. The currents were activated by a 50 ms voltage step to +100 mV from a prepulse of -180 mV with intracellular 10M Ca2+.
Molecular Weight 4313
Application Notes 10-100 nM
Comment

K+ channel toxin -KTx 1.1, ChTX, ChTX-Lq1, ChTx-a.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.160ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Supplier Images
 image for rCharybdotoxin (ABIN1001667) mSlo channel currents, before and during application of 100nM rCharybdotoxin. The cur...
Background publications Meera, Wallner, Toro: "A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 10, pp. 5562-7, 2000 (PubMed).

Product cited in: Vita, Bontems, Bouet, Tauc, Poujeol, Vatanpour, Harvey, Menez, Toma: "Synthesis of charybdotoxin and of two N-terminal truncated analogues. Structural and functional characterisation." in: European journal of biochemistry / FEBS, Vol. 217, Issue 1, pp. 157-69, 1993 (PubMed).

Gimenez-Gallego, Navia, Reuben, Katz, Kaczorowski, Garcia: "Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 10, pp. 3329-33, 1988 (PubMed).

Smith, Phillips, Miller: "Purification of charybdotoxin, a specific inhibitor of the high-conductance Ca2+-activated K+ channel." in: The Journal of biological chemistry, Vol. 261, Issue 31, pp. 14607-13, 1986 (PubMed).

Miller, Moczydlowski, Latorre, Phillips: "Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle." in: Nature, Vol. 313, Issue 6000, pp. 316-8, 1985 (PubMed).

镇原县| 景德镇市| 黄浦区| 始兴县| 高淳县| 慈溪市| 云南省| 辽中县| 凤冈县| 石狮市| 固阳县| 新巴尔虎左旗| 兰坪| 浮梁县| 莆田市| 汪清县| 武鸣县| 隆林| 阿勒泰市| 西充县| 山东| 兴山县| 南郑县| 栖霞市| 阳山县| 图木舒克市| 任丘市| 丹东市| 澄江县| 自贡市| 平远县| 桐梓县| 石家庄市| 巴林左旗| 泰安市| 合江县| 黄梅县| 武宁县| 卓资县| 渝中区| 东乡族自治县|