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產(chǎn)品名稱：rlberiotoxin(IbTx)
產(chǎn)品型號：
產(chǎn)品廠商：BioLeaf
產(chǎn)品文檔：

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簡單介紹：

rlberiotoxin(IbTx)

詳情介紹：

Product details
Product details
Sequence	QFTDVDCSVS KECWSVCKDL FGVDRGKCMG KKCRCYQ.
Specificity	Iberiotoxin is a potent selective blocker of the high conductance Ca2+-activated K+ channels (maxi-K).
Characteristics	Source: Mesobuthus tamulus (Eastern Indian scorpion). Molecular formula: C₁₇₉H₂₇₇N₅₁O₅₅S₇. Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35.
Purity	> 98 %

Target details
Target details
Background	Inhibition of BKCa channels heterologously expressed in HEK293 cells by Iberiotoxin. mSlo channel currents, before and during application of 100nM rIberiotoxin. The mSlo currents were activated by a 50 ms voltage step to +100 mV from a prepulse of -180 mV with intracellular 10 M Ca2+.
Molecular Weight	4248

Application Details
Application Details
Application Notes	50-100 nM
Comment	K+ channel toxin -KTx 1.3
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). Concentration after reconstitution: Dissolving 50 g in 1.175ml will provide a stock solution of 10 M.
Handling Advice	Soluble in Water.

Images
Images
Supplier Images	mSlo channel currents, before and during application of 100nM rIberiotoxin. The mSlo ... mSlo channel currents, before and during application of 100nM rIberiotoxin. The mSlo currents were activated by a 50 ms voltage step to +100 mV from a prepulse of -180 mV with intracellular 10 μM Ca2+. mSlo channel currents, before and during application of 100nM rIberiotoxin. The mSlo currents were activated by a 50 ms voltage step to +100 mV from a prepulse of -180 mV with intracellular 10 μM Ca2+.

References
References
Background publications	Meera, Wallner, Toro: "A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 10, pp. 5562-7, 2000 (PubMed).
Product cited in:	Koschak, Koch, Liu, Kaczorowski, Reinhart, Garcia, Knaus: "[125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels." in: Biochemistry, Vol. 36, Issue 7, pp. 1943-52, 1997 (PubMed). Galvez, Gimenez-Gallego, Reuben, Roy-Contancin, Feigenbaum, Kaczorowski, Garcia: "Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus." in: The Journal of biological chemistry, Vol. 265, Issue 19, pp. 11083-90, 1990 (PubMed).

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