Background
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The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE and the PtdIns(3,5)P2 phosphatase FIG4. VAC14 functions as an activator of PIKFYVE.
Alias Symbols: ArPIKfyve, FLJ10305, FLJ36622, FLJ46582, MGC149815, MGC149816, TAX1BP2, TRX
Protein Interaction Partner: NOS1,EIF4A2,FIG4,PIKFYVE,VAC14
Protein Size: 781
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